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Review
articles
Wahren J, Ekberg K, Shafqat J, Johansson J, Johansson B-L, Jörnvall
H: Biological effects of C-peptide and proinsulin. In International
Textbook of Diabetes Mellitus DeFronzo R, Ferranninni E, Keen H, Zimmet P,
Eds. Chichester, John Wiley, 2004, p. 165-182
Johansson J, Ekberg
K, Shafqat J, Henriksson M, Chibalin A, Wahren J, Jörnvall H: Molecular
effects of proinsulin C-peptide. Biochemical & Biophysical Research
Communications 295:1035-1040, 2002
Wahren J, Ekberg K,
Samnegård B, Johansson B-L: C-peptide: a new potential in the treatment
of diabetic nephropathy. Current Diabetes Reports 1:261-266, 2001
Cellular effects of C-peptide
Zhong Z, Kotova O, Davidescu A, Ehrén I, Ekberg K, Wahren J, Chibalin A: C-
peptide stimulates Na+,K+-ATPase via activation of ERK1/2 MAP kinases in human
renal tubular cells. Cell Mol Life Sci 61:2782-2790, 2004
Zhong Z, Davidescu A, Ehrén I, Ekberg K,
Jörnvall H, Wahren J, Chibalin A: C-peptide stimulates ERK1/2 and JNK MAP kinases via
activation of PKC in human renal tubular cells. Diabetologia 48.187-197, 2005
Shafqat J, Juntti-Berggren
L, Zhong Z, Ekberg K, Köhler M, Berggren P-O, Johansson J, Wahren
J, Jörnvall H: Proinsulin C-peptide and its analogues induce intracellular
Ca2+ increases in human renal tubular cells. Cell Mol Life Sci
59:1185-1189, 2002
Pramanik A, Ekberg
K, Zhong Z, Shafqat T, Henriksson M, Tally M, Tibell A, Jansson O, Wahren
J, Jörnvall H, Rigler R, Johansson J: C-peptide binding to human
cell membranes: importance of Glu27. Biochem Biophys Res Commun
284:94-98, 2001
Kitamura T, Kimura
K, Okamoto S, Canas X, Sakane N, Yoshida T, Saito M: Proinsulin C-peptide
rapidly stimulates mitogen-activated protein kinases in Swiss 3T3 fibroblasts:
requirement of protein kinase C, phosphoinositide 3-kinase and pertussis
toxin-sensitive G-protein. Biochem. J. 355:123-129, 2001
Rigler R, Pramanik
A, Jonasson P, Kratz G, Jansson O, Nygren P-Å, Ståhl S, Ekberg
K, Johansson B-L, Uhlén S, Uhlén M, Jörnvall H, Wahren
J: Specific binding of proinsulin C-peptide to human cell membranes. Proc.
Natl. Acad. Sci. USA 96:13318-13323, 1999
Ohtomo Y, Bergman
T, Johansson B-L, Jörnvall H, Wahren J: Differential effects of proinsulin
C-peptide fragments on Na+,K+-ATPase activity of renal tubule segments.
Diabetologia 41:287-291, 1998
Ohtomo Y, Aperia A,
Sahlgren B, Johansson B-L, Wahren J: C-peptide stimulates rat renal tubular
Na+,K+ATPase activity in synergism with neuropeptide Y. Diabetologia
39:199-205, 1996
Nerve function
Ekberg K, Brismar T, Johansson B-L, Jonsson B, Lindström P, Wahren
J: Amelioration of sensory nerve dysfunction by C-peptide in patients
with type 1 diabetes. Diabetes:52: 536-541, 2003
Zhang W, Yorek M,
Pierson C, Murakawa Y, Breidenbach A, Sima A: Human C-peptide dose dependently
prevents early neuropathy in the BB/Wor rat. Int J Experimental Diab
Res 2:187-193, 2001
Cotter M, Cameron
N: C-peptide effects on nerve conduction and blood flow in streptozotocin-induced
diabetic rats: modulation by nitric oxide synthase inhibition. Diabetes
50:A184, 2001
Sima A, Zhang W, Sugimoto
K, Henry D, Li Z, Wahren J, Grunberger G: C-peptide prevents and improves
chronic type 1 diabetic neuropathy in the BB/Wor rat. Diabetologia
44:889-897, 2001
Johansson B-L, Borg
K, Fernqvist-Forbes E, Kernell A, Odergren T, Wahren J: Beneficial effects
of C-peptide on incipient nephropathy and neuropathy in patients with
type I diabetes - a three-month study. Diabetic Medicine 17:181-189,
2000
Ido Y, Vindigni A,
Chang K, Stramm L, Chance R, Heath W, DiMarchi R, DiCera E, Williamson
J: Prevention of vascular and neural dysfunction in diabetic rats by C-peptide.
Science 277:563-566, 1997
Johansson B-L, Borg
K, Fernqvist-Forbes E, Odergren T, Remahl S, Wahren J: C-peptide improves
autonomic nerve function IDDM patients. Diabetologia 39:687-695,
1996
Renal function
Huang D-Y, Richter K, Breidenbach A, Vallon V: Human C-peptide acutely
lowers glomerular hyperfiltration and proteinuria in diabetic rats: a
dose-response study. Naunyn Schmiedebergs Arch Pharmacol 365:67-73,
2002
Samnegård B,
Jacobson S, Jaremko G, Johansson B-L, Sjöquist M: Effects of C-peptide
on glomerular and renal size and renal function in diabetic rats. Kidney
Int 60:1258-1265, 2001
Johansson B-L, Borg
K, Fernqvist-Forbes E, Kernell A, Odergren T, Wahren J: Beneficial effects
of C-peptide on incipient nephropathy and neuropathy in patients with
type I diabetes - a three-month study. Diabetic Medicine 17:181-189,
2000
Johansson B-L, Sjöberg
S, Wahren J: The influence of human C-peptide on renal function and glucose
utilization in Type I (insulin-dependent) diabetic patients. Diabetologia
35:121-128, 1992
Myocardial function
Hansen A, Johansson B-L, Wahren J, Bibra von H: C-peptide exerts beneficial
effects on myocardial blood flow and function in patients with type 1
diabetes. Diabetes 51:3077-3082, 2002
Johansson B-L, Sundell
J, Ekberg K, Jonsson C, Wahren J, Nuutila P, Knuuti J, Raitakari O, Seppänen
M, Luotolahti M: Adenosine-induced myocardial vasodilatation is improved
by C-peptide in type 1 diabetes. Diabetologia 45 (suppl 2):A197,
200
Young L, Ikeda Y,
Scalia R, Lefer A: C-peptide exerts cardioprotective effects in myocardial
ischemia-reperfusion. Am J Physiol Heart Circ 279:H1453-H1459,
2000
Blood flow
Fernqvist-Forbes E, Johansson B-L, Eriksson M: Effects of C-peptide on
forearm blood flow and brachial artery dilatation in patients with type
1 diabetes. Acta. Physiol. Scand. 172:159-165, 2001
Kunt T, Schneider
S, Pfützner A, Goitum K, Engelbach M, Schauf B, Beyer J, Forst T:
The effect of human proinsulin C-peptide on erythrocyte deformability
in patients with type 1 diabetes mellitus. Diabetologia 42:465-471,
1999
Jensen J, Messina
E: C-peptide induces a concentration-dependent dilation of skeletal muscle
arterioles only in presence of insulin. Am J Physiol Heart Circ
276:H1223-H1228, 1999
Forst T, Kunt T, Pohlmann
T, Goitom K, Engelbach M, Beyer J, Pfützner A: Biological activity
of C-peptide on the skin microcirculation in patients with insulin dependent
diabetes mellitus. J. Clin. Invest. 101:2036-2041, 1998
Lindström K,
Johansson C, Johnsson E, Haraldsson B: Acute effects of C-peptide on the
microvasculature of isolated perfused skeletal muscle and kidneys in rat.
Acta. Physiol. Scand. 156:19-25, 1996
Johansson B-L, Linde
B, Wahren J: Effects of C-peptide on blood flow, capillary diffusion capacity
and glucose utilization in the exercising forearm of Type I (insulin-dependent)
diabetic patients. Diabetologia 35:1151-1158, 1992
Glucose metabolism
Li Z-G, Qiang X, Sima A, Grunberger G: C-peptide attenuates protein tyrosine
phosphatase activity and enhances glycogen synthesis in L6 myoblasts.
Biochem Biophys Res Commun 280:615-619, 2001
Ling L, Oshida Y,
Kusunoki M, Yamanouchi K, Johansson B-L, Wahren J, Sato Y: Rat C-peptide
I and II stimulate glucose utilization in STZ-induced diabetic rats. Diabetologia
42:958-964, 1999
Zierath J, Handberg
A, Tally M, Wallberg-Henriksson H: C-peptide stimulates glucose transport
in isolated human skeletal muscle independent of insulin receptor and
tyrosine kinase activation. Diabetologia 39:306-313, 1996
Zierath J, Galuska
D, Johansson B-L, Wallberg-Henriksson H: Effect of human C-peptide on
glucose transport in in vitro incubated human skeletal muscle. Diabetologia
34:899-901, 1991
Other
Fredriksson A, Ekberg K, Ingvar M, Johansson B-L, Wahren J, Stone-Elander
S: In vivo biodistribution and pharmacokinetics of 18F-labeled human C-peptide:
evaluation in monkeys using positron emission tomography. Life Sciences
71:1361-1370, 2002
Leclercq-Meyer V,
Malaisse WJ, Johansson B-L, Wahren J: Effect of C-peptide on insulin and
glucagon released by isolated perfused rat pancreas. Diabetes &
Metabolism 23:149-154, 1997
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